j.biol.chem发表论文

姓名:林海燕学科:发育生物学电话/传真:+86-10-64807189 / +86-10-64807187电子邮件:通讯地址:北京市朝阳区北辰西路1号院5号中国科学院动物研究所 计划生育生殖生物学国家重点实验室 100101更多信息:生殖生理学研究组 简历：林海燕，女，博士，副研究员。1997和2000年获北京师范大学学士和硕士学位。2005年获中国科学院动物研究所博士学位。2006年至2008年在加拿大温哥华不列颠哥伦比亚大学妇产科系做博士后，主要从事皮质醇结合球蛋白CBG（负责转运孕酮与皮质醇）基因转录调控和蛋白质功能研究。多年来一直从事胚胎植入、胎盘发育的分子机理研究，目前主要进行“CBG在人胎盘中的功能及其多态性与先兆子痫发病的关系”研究。主持国家自然科学基金面上项目、青年基金项目和中国科学院院长基金特别资助项目等。近几年间在J Biol Chem等期刊发表SCI收录论文32篇（第一作者/通讯作者10篇）。研究领域：主要从事皮质醇结合球蛋白CBG（负责转运孕酮与皮质醇）基因转录调控和蛋白质功能研究。社会任职：获奖及荣誉：承担科研项目情况：代表论著：Lin HY, Underhill C, Gardill BR, Muller YA, Hammond GL. Residues in the human corticosteroid-binding globulin reactive center loop that influence steroid binding before and after elastase cleavage. J Biol Chem, 2009, 284, 884-896. Lin HY*, Muller YA, Hammond GL*. Molecular and structural basis of steroid hormone binding and release from corticosteroid-binding globulin. Mol Cell Endocrinol, 2010, 316, 3-12. Yang Q, Chen SP, Zhang XP, Wang H, Zhu C, Lin HY*. Smurf2 participates in human trophoblast cell invasion by inhibiting TGF-beta type I receptor. J Histochem Cytochem, 2009, 57:605-612. Lin HY, Yang Q, Wang HM, Qi JG, Zhang H, Wang HX, Tsang BK, Zhu C. Involvement of SMAD4, but not of SMAD2, in transforming growth factor-β1-induced trophoblast expression of matrix metalloproteinase-2. Front Biosci, 2006, 11, 637-646. Lin HY, Zhang H, Yang Q, Wang HX, Wang HM, Chai KX, Chen LM, Zhu C. Expression of prostasin and protease nexin-1 in rhesus monkey (Macaca mulatta) endometrium and placenta during early pregnancy. J Histochem Cytochem, 2006, 54, 1139-1147. Lin HY, Qian D, Zhang X, Liu GY, Wang HM, Zhu C. Gene expression of transforming growth factor-β receptors types I and II in rat endometrium during the estrous cycle and early pregnancy. Life Sci, 2006, 78, 2669-2675. Luo S, Lin HY (co-first author), Qi JG, Wang YC. Effects of sense and antisense centromere/kinetochore complex protein-B (CENP-B) in cell cycle regulation. Chinese Sci Bull, 2005, 50, 2836-2843. Lin HY, Wang HM, Li QL, Liu DL, Zhang X, Liu GY, Qian D, Zhu C. Expression of Smad2 and Smad4, transforming growth factor-β signal transducers, in rat endometrium during the estrous cycle, pre-, and peri-implantation. Anim Reprod Sci, 2004, 80, 303-316. Lin HY, Wang HM, Zhu C. The Smad pathway in transforming growth factor-β signaling. Sci China (Series C), 2003, 46, 449-463. Lin HY, Wang HM, Li QL, Wang J, Zhang X, Liu DL, Liu HT, Zhu C. Expression of Smad2 and Smad4 in rhesus monkey endometrium during the menstrual cycle and early pregnancy. Prog Nat Sci, 2003, 13, 584-589. 林海燕, 王红梅, 祝诚. 转化生长因子-β对基质金属蛋白酶及其组织抑制因子调控的研究进展. 生物化学与生物物理进展, 2003, 30, 7-12. (封面文章) Zhang H, Lin HY, Yang Q, Wang HX, Chai KX, Chen LM, Zhu C. Expression of Prostasin Serine Protease and Protease Nexin-1 (PN-1) in Rhesus Monkey Ovary During Menstrual Cycle and Early Pregnancy. J Histochem Cytochem, 2007, 55, 1237-1244. Yang Q, Lin HY, Wang HX, Zhang H, Zhang XP, Wang HM, Zhu C. Expression of Smad Ubiquitin Regulatory Factor 2 (Smurf2) in Rhesus Monkey Endometrium and Placenta During Early Pregnancy. J Histochem Cytochem, 2007, 55, 453-460. Zhang X, Lin HY, Liu GY, Wang HM, Li QL, Zhu C. Expression and regulation of endothelial and inducible nitric oxide synthases in mouse uterus during the estrous cycle and early pregnancy. Front Biosci, 2005, 10, 3172-3182. Qian D, Lin HY, Wang HM, Zhang X, Liu DL, Li QL, Zhu C. Normoxic Induction of the Hypoxic-Inducible Factor-1α by Interleukin-1β Involves the Extracellular Signal-Regulated Kinase 1/2 Pathway in Normal Human Cytotrophoblast Cells. Biol Reprod, 2004, 70, 1822-1827. Liu GY, Lin HY, Zhang X, Li QL, Wang HM, Qian D, Zhu C. Expression of Smad2 and Smad4 in Mouse Uterus during the Estrous Cycle and Early Pregnancy. Placenta, 2004, 25, 530-537. Qian D, Lin HY, Wang HM, Zhang X, Li QL, Liu DL, Zhu C. Involvement of ERK1/2 Pathway in TGF-β1-induced VEGF Secretion in Normal Human Cytotrophoblast Cells. Mol Reprod Dev, 2004, 68, 198-204. Zhang B, Zhou Z, Lin H, Lv X, Fu J, Lin P, Zhu C, Wang H. Protein phosphatase 1A (PPM1A) is involved in human cytotrophoblast cell invasion and migration. Histochem Cell Biol, 2009, 169-179. Zhang H, Li Q, Lin H, Yang Q, Wang H, Zhu C. Role of PPARgamma and its gonadotrophic regulation in rat ovarian granulosa cells in vitro. Neuro Endocrinol Lett, 2007, 28, 289-294. Zhang X, Zhu C, Lin H, Yang Q, Ou Q, Li Y, Chen Z, Racey P, Zhang S, Wang H. Wild fulvous fruit bats (Rousettus leschenaulti) exhibit human-like menstrual cycle. Biol Reprod, 2007, 77, 358-364. Wang HX, Wang HM, Lin HY, Yang Q, Zhang H, Tsang BK, Zhu C. Proteasome subunit LMP2 is required for matrix metalloproteinase-2 and -9 expression and activities in human invasive extravillous trophoblast cell line. J Cell Physiol, 2006, 206, 616-623. Liu GY, Zhang X, Lin HY, Wang HM, Li QL, Ni J, Zhu C. Effects of E-cadherin on mouse embryo implantation and expression of matrix metalloproteinase-2 and -9. Biochem Biophys Res Commun, 2006, 343, 832-838. Zhang X, Wang HM, Lin HY, Liu GY, Li QL, Zhu C. Regulation of Matrix Metalloproteinases (MMPs) and their Inhibitors (TIMPs) during Mouse Peri-implantation: Role of Nitric Oxide. Placenta, 2004, 25, 243-252. Wang HM, Li QL, Lin HY, Yu XD, Qian D, Dai JJ, Duan EK, Zhu C. Expression of vascular endothelial growth factor and its receptors in the rhesus monkey (Macaca mulatta) endometrium and placenta during early pregnancy. Mol Reprod Dev, 2003, 65,123-131. Qian D, Wang HM, Lin HY, Zhang X, Li QL, Liu DL, Liu GY, Zhu C. Effect of UPP on the expression of VEGF and its receptors in mouse uterus during peri-implantation. Chin Sci Bull, 2003, 48, 338-342. Li QL, Wang HM, Lin HY, Zhu C. Expression of gelatinases and their tissue inhibitors in rat corpus luteum during pregnancy and postpartum. Mol Reprod Dev. 2002, 63, 273-281. Liu DL, Li QL, Lin HY, Liu WZ, Wang HM, Zhang X, Zhu C. Expression and localization of RAP250 mRNA in the rat ovary: Possible implications in follicular development and ovulation. Endocrine, 2002, 18, 173-178. Li QL, Wang HM, Lin HY, Shao LJ, Ni J, Duan EK, Zhu C. Expression of VEGF in the pregnant and postpartrum rat ovaries. Sci China (C), 2002, 45, 379-387. Zhang X, Wang HM, Lin HY, Li QL, Liu DL, Qian D, Liu GY, Zhu C. Regulation of blastocyst implantation by nitric oxide in mouse. Chinese Sci Bul,2002, 47, 1461-1465. Yang Q, Wang HX, Zhao YG, Lin HY, Zhang H, Wang HM, Sang QA, Zhu C. Expression of tissue inhibitor of metalloproteinase-4 (TIMP-4) in endometrium and placenta of rhesus monkey (Macaca mulatta) during early pregnancy. Life Sci, 2005, 78, 2804-2811. Wang HM, Zhang X, Qian D, Lin HY, Li QL, Liu DL, Liu GY, Yu XD, Zhu C. Effect of ubiquitin-proteasome pathway on mouse blastocyst implantation and expression of matrix metalloproteinases-2 and -9. Biol Reprod, 2004, 70, 481-487. Wang HX, Wang HM, Li QL, Lin HY, Qian D, Zhu C. Expression of Proteasome Subunits LMP2 and LMP7 in the Endometrium and Placenta of Rhesus Monkey (Macaca mulatta) During Early Pregnancy. Biol Reprod, 2004, 71, 1317-1324. Li QL, Wang HM, Zhao YG, Lin HY, Sang QA, Zhu C. Identification and specific expression of endometase/matrilysin-2 (MMP-26) in endometrium of rhesus monkey during early pregnancy. Mol Hum Reprod, 2002, 8, 934-940. Zhou Z, Shen T, Zhang BH, Lv XY, Lin HY, Zhu C, Xue LQ, Wang H. The proprotein convertase furin in human trophoblast: Possible role in promoting trophoblast cell migration and invasion. Placenta, 2009, 30, 929-938. Wang HX, Zhao YG, Wang HM, Yang Q, Lin HY, Sang QA, Zhu C. Expression of adamalysin 19/ADAM19 in the endometrium and placenta of rhesus monkey (Macaca Mulatta) during early pregnancy. Mol Hum Reprod, 2005, 11, 429-435.

姬新颖简历

姬新颖

简介

男，博士、教授、留美学者、硕士生导师、归侨、省市侨联委员、无党派人士。1963年10月生，河南新安县人。1999.7获第四军医大学内科学感染病专业博士。1993.10-1994.1赴澳大利亚访问，2000-2009在美国学习与工作，曾任美国肯塔基大学医学院内科研究助理教授等。 2009.4月回国。现任河南大学医学院副院长(2011年12月), 主管科研、研究生教育、国际交流、学位点建设。承担了3项国家自然科学金基面上项目,获得科研经费123万元。指导研究生10余名,发表SCI论文15篇。2011年获得开封市优秀教师，2013年6月获得《科学中国人》2012年度人物奖。Tumor Biology(SCI IF 2.3)， BMC Cancer(SCI IF 3.1)审稿人。现任省免疫学会重症肌无力分会副主委、国家自然科学基金微生物学科和肿瘤学科项目评议人、河南大学医学微生物学双语教学课程负责人。曾担任省高层次人才引进评价绿色通道评委;河南大学学报(医学版)编委会委员、特聘英文编辑。河南省第七批重点学科(2009-2011)---病理与病理生理学科第一带头人，河南省医学重点学科人体免疫学科带头人(2011-2015)。

一、 近年主持的主要科研项目

1.2006.1-2008.12：国家自然科学基金面上项目, 负责人。 课题名称:树突状细胞

Toll样受体对丙型肝炎病毒单链RNA分子的感受及信号转导 。编号：30570086。 经费：26万元。

2. 2010.1-2012.12: 河南大学省部共建项目,项目负责人,课题名称: 感染引起膈肌肌

无力的信号转导通路和药物靶点筛选。编号:SBGJ090712。经费：9万元。

3. 2010.1-2014.12: 国际合作项目(与美国宾夕法尼亚大学医学院终身教授,河南大学

4. 2011.1-2013.12: 国家自然科学基金面上项目, 负责人。 课题名称: P38信号转道

通路在感染致膈肌无力中的作用。编号：81071327。经费：32万元。

5. 2011.1-2013.12:河南省科技厅国际合作项目，负责人。课题名称：基于大动脉血

流动力学特点和内皮细胞基因表达谱的抗动脉粥样硬化药物靶点筛选。编号：114 300 510 026。经费：4万元。

6. 2012.7.20: 河南省医学科技攻关计划,负责人。课题名称:冠状动脉内皮细胞异性诊

断标志物的筛选及其动脉粥样硬化性基因表达谱的.逆转。编号: 201204063。

7. 2013.1-2016.12：2012年国家自然科学基金面上项目, 课题组长，项目名称: JNK1

与TIPE2抑制剂改善感染后膈肌无力的分子机制。项目编号:81270142, 经费：70万元。

8. 2012.9.24：2012年度郑州市科技局科技发展计划项目， 负责人，项目名称: 冠

状动脉内皮细胞诊断标志物的筛选和动脉粥样硬化性表型的药物逆转。项目编号: 20120847。

二、代表性论文(*corresponding author)

Ying-Jie Ma, Min He, Ji-Ao Han, Li Yang, Xin-Ying Ji*. A clinical study of HBsAg-activated dendritic cells and cytokine-induced killer cells during the treatment of chronic Hepatitis B. Scand J Immunol. 2013 Oct;78(4):387-93. Tang Z, Bereczki E, Zhang H, Wang S, Li C, Ji X, Branca RM, Lehti? J, Guan Z, Filipcik P, Xu S, Winblad B, Pei JJ. Mammalian Target of Rapamycin (mTor) Mediates Tau Protein Dyshomeostasis: IMPLICATION FOR ALZHEIMER DISEASE. J Biol Chem. 2013 May 31; 288(22):15556-70.

Jingling Sun, Tengfei Chen, Xin-ying Ji(co-first), Changqin Liu, Praveen K. Yadav, Ruijin Wu, Pingchang Yang, Zhanju Liu. IL-25 downregulates Th1/Th17 immune response in an Il-10 dependent manner in inflammatory bowel diseases. Inflammatory Bowel Diseases. 2013 Mar-Apr; 19(4): 720-8.

Xin-Zheng Cui, Xin-Ying Ji*(correspondence, co-first), Feng Gao3, Kun-PengYang, Hui-Ling Bai, Hong-Bing Ma, Tao Li, Qing-Yong Zhang*. Evaluation of the new classification and surgical strategy for myasthenia gravis. American Surgeon, 2012, 78(12):1329-1335.

Tao Li, Wu-Ying Li, Hui-Ling Bai, Hong-Bing Ma, Hu Zhang, Jiang-Mu Zhu, Xiao-Hong Li, Hong-Ying Huang, Yuan-Fang Ma and Xin-Ying Ji*(correspondence). The genetic profiling of preferentially expressed genes in murine splenic CD8alpha+ dendritic cells. Immunologic Research, 2011, 51(1):80-96.

B-H Niu, J-J Wang, Y Xi , X-Y Ji*(correspondence). The establishment and characterization of adriamycin-resistant cell lines derived from Saos-2. Medical Science Monitor, 2010 Jun;16(6):BR184-92.

Shi ZD, Ji XY, Berardi DE, Qazi H, Tarbell JM. Interstitial flow induces MMP-1 expression and vascular SMC migration in collagen I gels via an ERK1/2-dependent and c-Jun-mediated mechanism. Am J Physiol Heart Circ Physiol. 2010 Jan; 298(1):H127-35. 2009 Oct 30.

Supinski GS, Ji XY, Callahan LA. p38 MAP Kinase Modulates Endotoxin induced Diaphragm Caspase Activation. Am J Respir Cell Mol Biol. 2010 Jul;43(1):121-7.

Shi ZD, Ji XY, Qazi H, Tarbell JM. Interstitial flow promotes vascular fibroblast, myofibroblast, and smooth muscle cell motility in 3-D collagen I via upregulation of MMP-1. Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1225-34. Epub 2009 May 22. Erratum in: Am J Physiol Heart Circ Physiol. 2009 Oct;297(4):H1225. ##

三、著 作

1. 肝硬化的诊断和治疗学, 周永兴主编，人民军医出版社，2001年，北京;参编“肝

硬化与免疫”一章，167-180页;

2. 感染病学, 21世纪系列教材，高等教育出版社，2000，北京; 参编“部分新出现的传染病”(267-276页)和“Internet与感染病学”(489-493页)二章。

耿美玉作为东京大学药学博士，曾经入选中国科学院的百人计划，然后获得过第十二届光华工程科技奖以及上海市三八红旗手标兵。