笨笨的2003
1.Farquhar, D.; Wang, Y. Novel antitumor organophosphates. The Cancer Bulletin Vol. 37, No.4. 167, 1985.2.Beran, M.; Andersson, B. S.; Wang, Y.; McCredie, K. B.; Farquhar, D. The effects of acetalaldophosphamide, a novel stable aldophosphamide analogue, on normal hu-man and leukemic progenitor cells in vitro: Implications for use in bone marrow purg-ing. Cancer Res. 48, 339, 1988.3.Andersson, B. S.; Wang, Y.; Farquhar, D. Stablein vitro active aldophosphamide acetals for bone marrow purging. Autologous Bone Marrow Transplantation, in pro-ceedings of the fourth international symposium. 1989.4.Andersson, B. S.; Wang, Y.; McCredie, K. B.; Farquhar, D. Suitability of a new stable acetal analogue of aldoifosphamide for purging leukemic cells from human bon-e marrow. Leukemia 6, 435, 1990.5.Wang, Y.; Farquhar, D. Aldophosphamide acetal diacetate and structural analogu-es: synthesis and cytotoxicity studies. J. Med. Chem. 34, 197, 1991.6.Wang, Y.; Liu, M. C.; Lin, T. S.; Sartorelli, A. C. Synthesis and biological evaluat-ion of novel antitumor 3- and 5-hydroxy-4-methyl-2-formylpyridine thiosemicarba-zones and their iron-chelates. J. Med. Chem. 35, 3667, 1992.7.Wang, Y.; Lown, J. L. An alternative method for synthesis of the CC-1065 pharm-acophore, 1,2,7,7a-tetrahydrocyclopropa[1,2-c]indol-4-one (CI). Heterocycl-es 36, 1399, 1993.8.Wang, Y.; Gupta, R.; Huang, L.; Lown, J. W. Synthesis and antitumor activity of CC-1065 functional analogues possessing different electron-withdrawing substitue-nts and leaving groups. J. Med. Chem. 36, 4172, 1993.9.Wang, Y.; Huang, L.; Wright, S. C.; Larrick, J. W. Synthesis and antitumor activ-ity studies of doxorubicin and DNA-minor groove binding oligopeptide conjuga-tes. Gene 149, 63, 1994.10.Fregeau, N. L.; Wang, Y.; Pon, R, T.; Wylie, W. A.; Lown, J. W. Characterization of a CPI-Lexitropsin Conjugate: Oligonucleotide covalent complex by 1H NMR and re-strained molecular dynamics simulation. J. Amer. Chem. Soc. 117, 8917, 1995.11.Wang, Y.; Gupta, R.; Huang, L.; Luo, W.; Lown, J. W. Design, synthesis, cyto-toxic properties and preliminary DNA sequencing evaluation of CPI-N-methy-lpyrrole hybrids. Enhancing effect of a trans double bond linker and role of the terminal amide functionality on cytotoxic potency. Anti-Cancer Drug Design 11, 15, 1996.12.Wright, S. C.; Schellenberger, U.; Wang, H.; Wang, Y.; Kinder, D. H. Chemother-apeutic drug activation of the AP24 protease in apoptosis: Requirement for caspase 3-like proteases. Biochem. Biophys. Res. Commun. 245, 797, 1998.13.Wang, Y.; Yuan, H.; Ye, W.; Wang, H.; Wright, S. C.; Larrick, J. W. Synthesis and pre-liminary biological evaluations of CC-1065 analogs: effects of different link-ers and terminal amides on biological activity. J. Med. Chem. 43, 1541. 2000.14.Wang, Y.; Yuan, H.; Wright, S. C.; Wang, H.; Larrick, J. W. Synthesis and pre-liminary cytotoxicity study of a cephalosporin-CC-1065 analogue. BMC Chemical Biology 1, 4, 2001.15.Wang, Y.; Yuan, H.; Wright, S. C.; Wang, H.; Larrick, J. W. Synthesis and cyto-toxicity of a biotinylated CC-1065 analogue. BMC Chemical Biology 2, 1. 2002.16.Wang, Y.; Wright, S. C.; Larrick, J. W. Synthesis and cytotoxicity of nitrogen mustard derivatives of distamycin A. Bioorg. Med. Chem. Lett. 13, 461, 2003.17.Wang, Y.; Ye, W.; Li, L.; Tian, Z.; Jiang, W.; Wang, H.; Wright, S. C.; Larrick, J. W. CC-1065 analogues bearing different DNA-binding subunits: synthesis, antitumor activity and preliminary toxicity study. J. Med. Chem. 46, 634, 2003.18.Wang, Y.; Yuan, H.; Wang, H.; Wright, S. C.; Larrick, J. W. Synthesis and pre-liminary cytotoxicity study of glucuronide derivatives of CC-1065 analogues. Bioorg. Med. Chem. 11, 1569, 2003.19.Wang, X.; Wang, Y.; Zheng, C. Isolation and purification of honokiol and magno-lol from Cortex Magnoliae Officinalis by high-speed counter-current chromatogra-phy. J. Chromatography A., 1036, 171, 2004.20.Wang, X.; Wang, Y.; Yuan, J.; Sun, Q.; Liu, J.; Zheng, C. An efficient new me-thod for extraction, separation and purification of psoralen and isopsoralen from Fructus Psoraleae by supercritical fluid extraction and high-speed counter-current chromatography. J. Chromatography A, 1055, 135, 2004.21.Wang, Y.; Li, L.; Jiang, W.; Larrick, J. W. Synthesis and evaluation of a DHA and 10-hydroxcamptothecin conjugate. Bioorg. Med. Chem. 13, 5592–5599, 2005.22.Wang, Y.; Li, L.; Jiang, W.; Yang, Z.; Zhang, Z. Synthesis and preliminary anti-tumor activity evaluation of a DHA and doxorubicin conjugate. Bioorg. Med. Chem. Lett. 16， 2974–2977，2006. 23.Wang, Y.; Li, L.; Tian, Z.; Jiang, W.; Larrick, J. W. Synthesis and antitumor act-ivity of CBI-bearing ester and carbamate prodrugs of CC-1065 analogue. Bioorg. Med. Chem. 14, 7854–7861, 2006.24.Wang, Y.; Eu, J.; Washburn, M.; Gong, T.; Chen, H. S. V.; Larrick, J. W.; Lipton, S. A.; Stamler, J, S.; Went, G. T.; Porter, S. The Pharmacology of Aminoadamantane nitrates. Curr. Alzheimer Res. 3, 201–204, 2006.25.Wang, Y., Yang, Z.; Wright, S. C.; Larrick, J. W. Synthesis and preliminary anti-tumor activity of distamycin nitrogen mustards. Lett. Drug Design and Discov. 4, 37–39, 2007.26.Suo, X. B.; Zhang, H.; Wang, Y. HPLC determination of andrographolide in rat whole blood: study on the pharmacokinetics of andrographolide incorporated in lipo-somes and tablets.Biomed Chromatogr. 21, 730–734, 2007.27.Suo, X. B.; Deng, Y. J.; Zhang, H.; Wang, Y. Degradation kinetics of waterinsol-uble lauroyl-indapamide in aqueous solutions: prediction of the stabilities of the drug in liposomes. Arch Pharm Res.30, 876–883, 2007. 28.Wang, Y.; Jiang, J.; Jiang, X.; Cai, S.; Han, H.; Li, L.; Tian, T.; Jiang, W.; Zhang, Z.; Xiao, Y.; Wei Wright, S. C.; Larrick, J. W. Synthesis and antitumor activ-ity eva-luations of albumin-binding prodrugs of CC-1065 analogue. Bioorg. Med. Chem. 16, 6552–6559, 2008.29.Sun, Y.; Jiang, J.; Zhang, Z.; Yu, P.; Wang, L.; Xu, C.; Liu, W.; Wang, Y. Anti-oxidative and thrombolytic TMP nitrone for treatment of ischemic stroke. Bioorg. Med. Chem. 16, 8868–8874, 2008.30.Chen, W-M.; Cheng, C.; Li, B-Z.; Ho, T-L.; Cai, Z-S.; Wang, Y.; Sun, P-H. Py-ridine-4-thiol and amphoteric analogs: novel Pprotection of aryl bromides in strong alkali. Helvetica Chimica Acta. 91, 2062–2068, 2008.31.Guo, J-L.; Li, B-Z.; Chen, W-M.; Sun, P-H.; Wang, Y. Synthesis of substituted 1H-pyrrol-2(5H)-ones and 2(5H)-furanones as inhibitors of P. aeruginosa biofilm. Lett. Drug Design and Discov. 6, 107–113, 2009.32.Jiang, X.; Yu, P.; Jiang, J.; Zhang, Z.; Wang, Z.; Yang, Z.; Tian, Z.; Wright, S. C.; Larrick, J. W.; Wang, Y. Synthesis and evaluation of antibacterial activities of andrographolide analogues. Eur. J. Med. Chem. 44, 2936–2943, 2009.33.Chen, J-X.; Xue, H-J.; Ye, W-C.; Fang, B-H., Liu, Y-H., Yuan, S-H., Yu, P.; Wang, Y. Activity of andrographolide and its derivatives against influenza virus in vivo and in vitro. Biol. Pharm. Bull. 32, 1385–1391, 2009.34.Zhang, Z.; Jiang, J.; Pei, Y.; Zeng, X.; Wang, Z.; Larrick, J. W.; Wang, Y.Hyp-oglycemic and beta cell protective andrographolide analogue for diabetes treat-ment. J. Translational Med. 7:62, 2009.35.Xu, J.; Huang, S.; Luo, H.; Li, G.; Bao, J.; Cai, S.; Wang, Y. QSAR studies on andrographolide derivatives as α-glucosidase inhibitors. Int. J. Mol. Sci. 11, 880–895, 2010.36.Wang, Z.; Yu, P.; Zhang, G.; Xu, L.; Wang, D.; Wang, L.; Zeng, X.; Wang, Y. Design, synthesis and antibacterial activity of novel andrographolide derivatives. Bioo-rg. Med. Chem. 18, 4269–4274, 2010.37.Sun, H.; Xu, L.; Yu, P.; Jiang, J.; Zhang, G.; Wang, Y. Synthesis and preliminary evaluation of neuroprotection of celastrol analogues in PC12 cells. Bioorg. Med. Che-m. Lett. 20, 3844–3847, 2010.38.Zhang, Z.; Li, S.; Jiang, J.; Yu, P.; Liang, J.; Wang, Y. Preventive effects of Flos puerariae lobatae water extract and its active ingredient puerarin in acute and chr-onic alcohol treated rat and mice model. Chinese Med. 5:36, 2010.39.Xu, J.; Lu, Y.; Luo, H.; Huang, S.; Bao, J.; Cai, S.; Wang Y. Homology modeling of α-glucosidase and its interactions with andrograpolide derivatives. Lett. Drug Desi-gn and Discov. 8, 440–451, 2011.40.Chen, H.; Li, S.; Wu, J.; Jiang, J.; Wang, Y. Pharmacokinetic study of a novel st-roke therapeutic, 2-[[(1,1-dimethylethyl)oxidoimino]methyl]-3,5,6-trimethy-lpyrazine, by a simple HPLC-UV method in rats. Eur. J. Drug. Metab. Ph. 36, 95–101, 2011.41.Zeng, X.; Liu, X.; Liang, H.; Bian J.; Pei, G.; Dai, H.; Polyak, S. W.; Song, F.; Ma, L.; Wang, Y.; Zhang, Z. Synergistic effect of AL-1 and various antibiotics on the fo-rmation of biofilms and production ofexopolysaccharide and pyocyanin by Pseu-domonas aeruginosa. Antimicrob. Agents Chemother. 55, 3015–3017, 2011.42.Cui, Q.; Zhang, G.; Yu, P.; Wang, Y. Synthesis and preliminary evaluation of anti-HIV agent AZT prodrug. Yao Xue Xue Bao. 46, 1015–1018, 2011.43.Lu, X.; Wan, S.; Jiang, J.; Jiang, X.; Yang, W.; Yu, P.; Xu, L.; Zhang, Z.; Zhang, G.; , Zaijun Z.; Shan, L.; Wang, Y. Synthesis and biological evaluations of novel apocynin analogues. Eur. J. Med. Chem. 46, 2691–2698. 2011.44.Cui, Q.; Zhang, G.; Yu, P.; Wang, Y. Synthesis and preliminary evaluation of an-tiHIV agent AZT prodrug. Acta Pharmaceutica Sinica, 46, 1015–1018, 2011.45.Yao, H.; Li, S.; Yu, P.; Tang, X.; Jiang, J.; Wang, Y. Reaction characteristics of andrographolide and its analogue AL-1with GSH as a simple chemical simulation of NF-κB Inhibition. Molecules 17, 728–739, 2011.46.Sun, Y.; Yu.; Zhang, G.; Wang, L.; Zhong, H.; Zhai, Z.; Wang, L.; Wang, Y. Therapeutic effects of tetramethylpyrazine nitrone in rat ischemic stroke models. J. Neurosci. Res. 90, 1662–1669, 2012.47.Sun, Y.; Zhang, G.; Zhang, Z.; Yu, P.; Zhong, H.; Du, J.; Wang, Y. Novel multi-functional nitrones for treatment of ischemic stroke. Bioorg. Med. Chem. 20, 3939–3945, 2012.48.Yu, P.; Xia, L.; Zhao, J.; Zhang, G.; Zhang, Z,; Lang, M.; Wang, Y. Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs. Biol. Pharm. Bull. 35, 1295–1299, 2012.49.Ma, Li.; Liu, X.; Liang, H.; Che, Y.; Dai, H.; Yu, K.; Liu, M.; Ma, L.; Yang, C-H.; Song, F.; Wang, Y.; Zhang, L. Molecular targets of 14-alpha-lipoyl andrographolide on quorum sensing inPseudomonas aeruginosa. Antimicrob. Agents Chemother. 56, 6088–6094, 2012.50.Cui, G.; Hung, M.; Shan, L.; Lei, S.; Choi, I.; Zhang, Z.; Hoi, M. P.; Yu, P.; Wang, Y.; Lee, S. M. A novel danshensu derivative confers cardioprotection via PI3K/Akt and Nrf2 pathways. Intl. J. Cardio. 168, 1349–1359, 2013.51.Zhu, Y.; Yu, G.; Zhang, Y.; Xu, Z.; Wang,Y.; Yan, G.;, He, Q. A novel androgra-pholide derivative AL-1 exerts its cytotoxicity on K562 cells through a ROS-dependent mechanism. Proteomics, 13,169–178, 2013.52.Cui, Q.; Shan, L.; Zhu, H.; Yu, P.; Wang, Y. Synthesis and preliminary evalu-ation of Danshensu derivatives modified at hydroxyl group. J. Intl. Pharm. Res. 40, 795–800, 2013.53.Yan, G.; Zhou, H.; Wang, Y.; Zhong, Y.; Tan, Z.; Wang, Y.; He, Q. Protective effects of andrographolide analogue AL-1 on ROS-induced RIN-m β cell death by inducing ROS generation. PLoS One, 8(6):e63656. doi: 10.1371, 2013.54.Talantovaa, M.; Sanz-Blascoa, S.; Zhang. X.; Xia, P.; Waseem Akhtara, M.; Ok-amotoa, S.; Dziewczapolskib, G.; Nakamuraa, T.; Gang, C.; Pratta, A. E.; Kanga, Y-J.; Tua, S.; Molokanovaa, E.; McKerchera, S. R.; Hiresd, A. A.; Sasone, H.; Sto-ufferf, D. G.; Buczynskif, M. W.; Solomong, J.; Michaelc, S.; Powersg, E. T.; Kell-yg, J. W.; Robertsj, A.; Tonga, G.; Fang-Newmeyera, T.; Parkera, J.; Hollanda, E. A.; Zhang, D.; Nakanishia, N.; Chen, H-S, V.; Woloskere, H.; Wang, Y.; Parsonsf, L. H.; Ambasudhana,R.; Masliahc, E.; Heinemannb, S. F.; Piña-Crespoa, J. C.; Lipton, S. A. Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activa-tion, and synaptic loss. PNAS, 110, E2518–2527, 2013.55.Xu, D.; Duan, H.; Du, J.; Zhang, Z.; Cui, W.; Wang, L.; Sun, Y.; Lang, M.; Hoi, P. M.; Han, Y.; Wang, Y.; Lee, S. M. The novel tetramethylpyrazine bis-nitrone (TN-2) protects against MPTP/MPP-induced neurotoxicity via inhibition of mitochondrial de-pendent apoptosis. J. Neuroimmun. Pharmacol. 2013 (advance online DOI 10.1007/s11481-013-9514-0).56.Guo, B.; Xu, D.; Duan, H.; Du, J.; Zhang, Z.; Lee, S. M.; Wang, Y. Therapeutic effects of multifunctional tetramethylpyrazine nitrone on models of Parkinson’s dis-ease in vitro andin vivo. Biol. Pharm. Bull. 37, 274–285, 2014.57.Cui, W.; Zhang, Z.; Hu, S.; Mak, S.; Xu, D.; Choi, C.; Wang, Y.; Tsim, K.; Lee, M.; Rong, J.; Han, Y. Sunitinib produces neuroprotective effect via inhibiting nitric oxide overproduction. CNS Neurosci. Ther. 2014 Jan 7. doi: 10.1111/cns.12203.58.Sun, Y.; Liao, K.; Li, S.; Zhang, Z.; Yu, P.; Wang, Y. Pharmacokinetic analysis of bis-nitrone tetramethylpyrazine (TN-2) in rats and its protein binding in vitro. Lett. Drug Design and Discov. 2014 (advance online).59.Lang, M.; Yan, R.; Wang, Y.; Yu, P. A selective O- and N-acylation protocol for carbamyl chloride. Chin. J. Org. Chem. 2014 (advance online).60.Cui, Q.; Chen, Y.; Zhang, M.; Shan, L.; Sun, Y.; Yu, P.; Zhang, G.; Wang, D.; Zhao, Z.; Xu, Q.; Xu, B.; Wang, Y. Design, synthesis and preliminary cardioprote-ctive effect evaluation of Danshensu derivatives. Chem. Biol.&DrugDes. 2014 (advance online).61.Li, S.; Shan, L.; Zhang, Z.; Li, W.; Liao, K.; Li, S.; Yu, P.; Wang, Y. Pharma-cokinetic and metabolism studies of ADTM, a novel Danshensu derivative confers cardioprotection by HPLC-UV and LC-MS/MS. J. Chromatogr. Sci. 2014 (advance online).62.Xu, L.; Li, Y.; Wan, S.; Wang, Y.; Yu, P. Apocynin nitrone protects rats from LPS-mediated acute lung injury via inhibition of NADPH oxidase. Intl. Immunophar-macol. 2014 (advance online).63.Du, E.; Liang, Z.; Xu, L.; Sun, S.; Zhang, G.; Yu, P.; Wang, Y. Synthesis and preliminary biologic activity evaluation of nitric oxide-releasing andrographolide ana-logues. Chem Pharma Bull. 2014 (advance online).64.Zhang, Z.; Lai, D.; Wang, L.; Pei, Y.; Zhu, L.; Guo, B.; Xu, L.; Sun, Y.; Xu, L.; Zhou, L.; Sun, Y.; Lee, S-M.; Wang, Y. Neuroprotective effects of the androgra-pholide analogue AL-1 in the MPP/MPTP-induced Parkinson’s disease model in vitro and in mice. Pharmacol. Biochem. Be. 2014 (advance online).
爱上大碴粥
If the Dream is Big EnoughI used to watch her from mykitchenwindow, she seemed so small as she 1)muscled her way throughthecrowd of boys on the playground. The school was across thestreetfrom our home and I would often watch the kids as theyplayedduring recess. A sea of children, and yet to me, she stoodout fromthem all.I remr the first day I saw her playing basketball.Iwatched in wonder as she ran circles around the other kids.Shemanaged to shoot jump shots just over their heads and into thenet.The boys always tried to stop her but no one could.I begantonotice her at other times, basketball in hand, playing alone.Shewould practice 2)dribbling and shooting over and overagain,sometimes until dark. One day I asked her why she practicedsomuch. She looked directly in my eyes and without a momentofhesitation she said, “I want to go to college. The only way Icango is if I get a scholarship. I like basketball. I decided thatifI were good enough, I would get a scholarship. I am going toplaycollege basketball. I want to be the best. My Daddy told me ifthedream is big enough, the facts don’t count.” Then she smiledandran towards the court to 3)recap the routine I had seen overandover again.Well, I had to give it to her—she was determined.Iwatched her through those junior high years and into highschool.Every week, she led her 4)varsity team to victory.One day inhersenior year, I saw her sitting in the grass, head cradled inherarms. I walked across the street and sat down in the coolgrassbeside her. Quietly I asked what was wrong. “Oh, nothing,”came asoft reply. “I am just too short.” The coach told her that at5’5”she would probably never get to play for a top ranked team—muchless offered a scholarship—so she should stop dreamingaboutcollege.She was heartbroken and I felt my own throat tightenas Isensed her disappointment. I asked her if she had talked to herdadabout it yet.She lifted her head from her hands and told methather father said those coaches were wrong. They just didnotunderstand the power of a dream. He told her that if shereallywanted to play for a good college, if she truly wantedascholarship, that nothing could stop her except one thing — herownattitude. He told her again, “If the dream is big enough, thefactsdon’t count.”The next year, as she and her team went totheNorthern California Championship game, she was seen by acollege5)recruiter. She was indeed offered a scholarship, a fullride, toa Division I, 6)NCAA women’s basketball team. She was goingto getthe college education that she had dreamed of and workedtoward forall those years.It’s true: If the dream is big enough,the factsdon’t count. 我以前常常从厨房的窗户看到她穿梭于操场上的一群男孩子中间，她显得那么矮小。 学校在我家的街对面，我可以经常看到孩子们在下课时间打球。尽管有一大群的孩子，但我觉得她跟其他的孩子截然不同。 我记得第一天看到她打篮球的情景。看着她在其他孩子旁边兜来转去，我感到十分惊奇。她总是尽力地跳起投篮，球恰好越过那些孩子的头顶飞入篮筐。那些男孩总是拼命地阻止她，但没有人可以做得到。 我开始注意到她有时候一个人打球。她一遍遍地练习运球和投篮，有时直到天黑。有一天我问她为什么这么刻苦地练习。她直视着我的眼睛，不加思索地说:“我想上大学。只有获得奖学金我才能上大学。我喜欢打篮球，我想只要我打得好，我就能获得奖学金。我要到大学去打篮球。我想成为最棒的球员。我爸爸告诉我说，心中有目标，风雨不折腰。”说完她笑了笑，跑向篮球场，又开始我之前见过的一遍又一遍的练习。 嘿，我服了她了——她是下定了决心了。我看着她这些年从初中升到高中。每个星期，她带领的学校篮球代表队都能够获胜。 高中那会儿的某一天，我看见她坐在草地上，头埋在臂弯里。我穿过街道，坐到她旁边的清凉的草地上。我轻轻地问出什么事了。“哦，没什么，”她轻声回答，“只是我太矮了。”原来篮球教练告诉她，以五英尺五英寸的身材，她几乎是没有机会到一流的球队去打球的——更不用说会获得奖学金了——所以她应该放弃想上大学的梦想。 她很伤心，我也觉得自己的喉咙发紧，因为我感觉到了她的失望。我问她是否与她的爸爸谈过这件事。 她从臂弯里抬起头，告诉我，她爸爸说那些教练错了。他们根本不懂得梦想的力量。他告诉她，如果真的想到一个好的大学去打篮球，如果她真的想获得奖学金，任何东西也不能阻止她，除非她自己不愿意。他又一次跟她说：“心中有目标，风雨不折腰。” 第二年，当她和她的球队去参加北加利福尼亚州冠军赛时，她被一位大学的招生人员看中了。她真的获得了奖学金，一个全面资助的奖学金，并且进入美国全国大学体育协会其中一队女子甲组篮球队。她将接受她曾梦想并为之奋斗多年的大学教育。 是的，心中有目标，风雨不折腰。
bigsunsun001
1 Department of Community Medicine, University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China,2 Department of Health, Student Health Service, 4/F Lam Tin Polyclinic, Kowloon, Hong Kong, China,3 Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX2 6HE Introduction Passive smoking can cause death from lung cancer and coronary heart disease, but there is little evidence for associations with other causes of death in never smokers. A recent study showed increased all cause mortality with exposure to secondhand smoke at home but did not examine associations with specific causes of death and dose-response relations.1 We have published estimates of the mortality attributable to active smoking in Hong Kong2 and now present the related findings on passive smoking at home. Participants, methods, and results Details of the sample selection and data collection have been reported.2 Each person who reported a death in 1998 at four death registries was given a questionnaire which asked about the lifestyle 10 years earlier of the decedent and of a living person about the same age who was well known to the informant. Passive smoking was identified in the interview with the question, "Ten years ago, in about 1988, excluding the decedent/control, how many persons who lived with the decedent/control smoked" Decedents or controls who lived with one or more smokers were classed as exposed. Cause of death was obtained from the death certificate. We selected never smoking decedents and controls aged 60 years or over because there were few younger controls. To avoid selection bias, we included only cases and controls who had a living spouse at the time of reporting. We used logistic regression to derive odds ratios adjusted for age and education, and for sex when men and women were combined. What is known on this topic There is strong evidence that passive smoking is causally associated with death from lung cancer, coronary heart disease, and all causes, and also with acute stroke What this study adds The dose-response relation between passive smoking and mortality from stroke and chronic obstructive pulmonary disease, as well as from lung cancer, ischaemic heart disease, and all causes of death, strengthens the causal link We identified 4838 never smoking cases (55% male) and 763 never smoking controls (55% male). All controls were used in the analysis for each specific cause of death. We found significant dose dependent associations between passive smoking and mortality from lung cancer, chronic obstructive pulmonary disease, stroke, ischaemic heart disease, and from all cancers, all respiratory and circulatory diseases, and all causes (table). The association between mortality and passive smoking did not differ between males and females. Deaths due to injury or poisoning were not associated with passive smoking. Number of subjects who were or were not exposed to secondhand smoke at home and odds ratios (adjusted for age and education, and for sex when men and women were combined) for mortality in people aged 60 or over, Hong Kong. Values are odds ratio (95% confidence interval) unless indicated otherwise Comment Dose dependent associations between passive smoking and causes of death are consistent with previous findings for lung cancer and coronary heart disease and extend the evidence on stroke. Previous studies have shown associations between passive smoking and first acute strokes,3 4 and we have now shown a dose-response relation with mortality from stroke. Previous studies focused on ischaemic strokes but Chinese populations have a greater incidence of haemorrhagic stroke than do white populations,5 implying that many of the strokes in our study may have been non-ischaemic. Passive smoking probably affects all stroke subtypes, as does active smoking. Our finding of a 34% increase in all cause mortality is consistent with but higher than that (15%) in the New Zealand cohort.1 Exposure to secondhand smoke at home is higher in Hong Kong than in New Zealand due to crowded living conditions. Before the 1990s, awareness of the danger of passive smoking was lower and smokers smoked freely at home. We focused on passive smoking at home because the proxy reporter could most reliably supply these data, and we adjusted for education, which was also reliably recorded2 and is a good proxy for social class in Hong Kong. As data on cases and controls were derived from the same proxy, reporting bias should be minimal.2 If our results are not due to residual confounding, they provide further evidence that the dose-response associations between passive smoking and stroke and all cause mortality are likely to be causal. See Editorial by Kawachi This article was posted on bmj.com on 27 January 2005: We thank W L Cheung for help with analysis; the Immigration Department of the Government of the Hong Kong Special Administrative Region for data and assistance; and, in particular, the relatives who provided information. Contributors: THL, SYH, AJH, KHM, and RP designed and carried out the study on which this analysis was based; SMcG, MS, LMH, and GNT planned and carried out this analysis; and all authors contributed to writing the paper. SMcG and THL are guarantors. Funding: Hong Kong Health Services Research Committee (#631012) and Hong Kong Council on Smoking and Health. Competing interests: THL is vice chairman and AJH a former chairman of the Hong Kong Council on Smoking and Health. Ethical approval: Ethics Committee of the Faculty of Medicine, University of Hong Kong. References Hill SE, Blakely TA, Kawachi I, Woodward A. Mortality among never smokers living with smokers: two cohort studies, 1981-4 and 1996-9. BMJ 2004;328: 988-9. Lam TH, Ho SY, Hedley AJ, Mak KH, Peto R. Mortality and smoking in Hong Kong: case-control study of all adult deaths in 1998. BMJ 2001;323: 361-2. Bonita R, Duncan J, Truelson T, Jackson RT, Beaglehole R. Passive smoking as well as active smoking increases the risk of acute stroke. Tobacco Control 1999;8: 156-60. Iribarren C, Darbinian J, Klatsky AL, Friedman GD. Cohort study of exposure to environmental tobacco smoke and risk of first ischemic stroke and transient ischemic attack. Neuroepidemiology 2004;23: 38-44. Kay R, Woo J, Kreel L, Wong HY, Teoh R, Nicholls MG. Stroke subtypes among Chinese living in Hong Kong: the Shatin stroke registry. Neurology 1992;42: 985-7.
*指尖的淚
means of mum`s loveTime is running out for my friend. While we are sitting at lunch she casually mentions she and her husband are thinking of starting a family. "We're taking a survey,"she says, half-joking. "Do you think I should have a baby?" "It will change your life," I say, carefully keeping my tone neutral. "I know,"she says, "no more sleeping in on weekends, no more spontaneous holidays..." But that's not what I mean at all. I look at my friend, trying to decide what to tell her. I want her to know what she will never learn in childbirth classes. I want to tell her that the physical wounds of child bearing will heal, but becoming a mother will leave her with an emotional wound so raw that she will be vulnerable forever. I consider warning her that she will never again read a newspaper without thinking: "What if that had been MY child?" That every plane crash, every house fire will haunt her. That when she sees pictures of starving children, she will wonder if anything could be worse than watching your child die. I look at her carefully manicured nails and stylish suit and think that no matter how sophisticated she is, becoming a mother will reduce her to the primitive level of a bear protecting her cub. I feel I should warn her that no matter how many years she has invested in her career, she will be professionally derailed by motherhood. She might arrange for child care, but one day she will be going into an important business meeting, and she will think her baby's sweet smell. She will have to use every ounce of discipline to keep from running home, just to make sure her child is all right.I want my friend to know that every decision will no longer be routine. That a five-year-old boy's desire to go to the men's room rather than the women's at a restaurant will become a major dilemma. The issues of independence and gender identity will be weighed against the prospect that a child molester may be lurking in the lavatory. However decisive she may be at the office, she will second-guess herself constantly as a mother. Looking at my attractive friend, I want to assure her that eventually she will shed the added weight of pregnancy, but she will never feel the same about herself. That her own life, now so important, will be of less value to her once she has a child. She would give it up in a moment to save her offspring, but will also begin to hope for more years—not to accomplish her own dreams—but to watch her children accomplish theirs. I want to describe to my friend the exhilaration of seeing your child learn to hit a ball. I want to capture for her the belly laugh of a baby who is touching the soft fur of a dog for the first time. I want her to taste the joy that is so real it hurts.My friend's look makes me realize that tears have formed in my eyes. "You'll never regret it," I say finally. Then, squeezing my friend's hand, I offer a prayer for her and me and all of the mere mortal women who stumble their way into this holiest of callings.时光任苒，朋友已经老大不小了。我们坐在一起吃饭的时候，她漫不经心地提到她和她的丈夫正考虑要小孩。“我们正在做一项调查，”她半开玩笑地说。“你觉得我应该要个小孩吗？”“他将改变你的生活。”我小心翼翼地说道，尽量使语气保持客观。“这我知道。”她答道，“周末睡不成懒觉，再也不能随心所欲休假了……”但我说的绝非这些。我注视着朋友，试图整理一下自己的思绪。我想让她知道她永远不可能在分娩课上学到的东西。我想让她知道：分娩的有形伤疤可以愈合，但是做母亲的情感伤痕却永远如新，她会因此变得十分脆弱。我想告诫她：做了母亲后，每当她看报纸时就会情不自禁地联想：“如果那件事情发生在我的孩子身上将会怎样啊！”每一次飞机失事、每一场住宅火灾都会让她提心吊胆。看到那些忍饥挨饿的孩子们的照片时，她会思索：世界上还有什么比眼睁睁地看着自己的孩子饿死更惨的事情呢？我打量着她精修细剪的指甲和时尚前卫的衣服，心里想到：不管她打扮多么考究，做了母亲后，她会变得像护崽的母熊那样原始而不修边幅。我觉得自己应该提醒她，不管她在工作上投入了多少年，一旦做了母亲，工作就会脱离常规。她自然可以安排他人照顾孩子，但说不定哪天她要去参加一个非常重要的商务会议，却忍不住想起宝宝身上散发的甜甜乳香。她不得不拼命克制自己，才不致于为了看看孩子是否安然无羔而中途回家。我想告诉朋友，有了孩子后，她将再也不能按照惯例做出决定。在餐馆，5岁的儿子想进男厕而不愿进女厕将成为摆在她眼前的一大难题：她将在两个选择之间权衡一番：尊重孩子的独立和性别意识，还是让他进男厕所冒险被潜在的儿童性骚扰者侵害？任凭她在办公室多么果断，作为母亲，她仍经常事后后悔自己当时的决定。注视着我的这位漂亮的朋友，我想让她明确地知道，她最终会恢复到怀孕前的体重，但是她对自己的感觉已然不同。她现在视为如此重要的生命将随着孩子的诞生而变得不那么宝贵。为了救自己的孩子，她时刻愿意献出自己的生命。但她也开始希望多活一些年头，不是为了实现自己的梦想，而是为了看着孩子们美梦成真。我想向朋友形容自己看到孩子学会击球时的喜悦之情。我想让她留意宝宝第一次触摸狗的绒毛时的捧腹大笑。我想让她品尝快乐，尽管这快乐真实得令人心痛。朋友的表情让我意识到自己已经是热泪盈眶。“你永远不会后悔，”我最后说。然后紧紧地握住朋友的手，为她、为自己、也为每一位艰难跋涉、准备响应母亲职业神圣的召唤的平凡女性献上自己的祈祷A Box Full Of Kisses Once upon a time, a man punished his 5-year-old daughter for using up the family's only roll of expensive gold wrapping paper. Money was tight, and he became even more upset when on Christmas Eve, he saw that the child had pasted the gold paper so as to decorate a shoebox to put under the Christmas tree. Nevertheless, the next morning the little girl, filled with excitement, brought the gift box to her father and said, "This is for you, Daddy!" As he opened the box, the father was embarrassed by his earlier overreaction. But when he opened it, he found it was empty and again his anger flared. "Don't you know, young lady,” he said harshly, “when you give someone a present there's supposed to be something inside the package!" The little girl looked up at him with tears rolling from her eyes and said: "Daddy, it's not empty. I blew kisses into it until it was all full." The father was crushed. He fell on his knees and put his arms around his precious little girl. He begged her to forgive him for his unnecessary anger. An accident took the life of the child only a short time later. It is told that the father kept that little gold box by his bed for all the years of his life. Whenever he was discouraged or faced difficult problems he would open the box, take out an imaginary kiss, and remember the love of this beautiful child who had put it there. In a very real sense, each of us as human beings have been given an invisible golden box filled with unconditional love and kisses from our children, family, friends and God. There is no more precious possession anyone could hold.从前,一位父亲惩罚了自己5岁的女儿,因为她用光了家里仅有的一卷昂贵的金色包装纸。家中余钱无多，在圣诞前夜来临时，父亲变得更加心烦意乱，他看到了圣诞树下的一个鞋盒，女儿原来把金纸贴在了这个鞋盒上做装饰。然而，圣诞日的早上，小女孩满是兴奋得把这个圣诞礼盒呈到了父亲面前，说到：“爸爸，这个送给你！”当父亲打开礼盒时，他为自己先前的过度反应而局促不安着。但是当他打开盒子后，发现里面是空的，他的怒火再次爆发了。“你不知道吗，小丫头，”他严厉地说，“当你送人礼物时，盒子里面应该是有东西的！”小女孩抬头看着气头上的父亲，泪水在她的眼眶中打圈：“爸爸，它不是空的。这里面装满了我的吻。”男人顿时被击垮了。他跪下双膝，双手环抱着自己珍爱的小女孩，祈求她的原谅。之后不久，一场事故夺走了小女孩的生命。据说，父亲便将那个小金盒子放在床头，一直陪伴着他的余生。无论何时他感到气馁或者遇到难办的事情，他就会打开礼盒，取出一个假想的吻，记起漂亮女儿给予了自己特殊的爱。从一个非常真实的意义上说，我们每个人都被赠与过一个无形的金色礼盒，那里面装满了来自子女，家人，朋友及上帝无条件的爱与吻。人们所能拥有的最珍贵的礼物莫过于此了。Love and Time Once upon a time, there was an island where all the feelings lived: Happiness, Sadness, Knowledge, and all of the others, including Love. One day it was announced to the feelings that the island would sink, so all constructed boats and left. Except for Love.Love was the only one who stayed. Love wanted to hold out until the last possible moment.When the island had almost sunk, Love decided to ask for help.Richness was passing by Love in a grand boat. Love said,"Richness, can you take me with you?"Richness answered, "No, I can't. There is a lot of gold and silver in my boat. There is no place here for you."Love decided to ask Vanity who was also passing by in a beautiful vessel. "Vanity, please help me!""I can't help you, Love. You are all wet and might damage my boat," Vanity answered.Sadness was close by so Love asked, "Sadness, let me go with you.""Oh . . . Love, I am so sad that I need to be by myself!"Happiness passed by Love, too, but she was so happy that she did not even hear when Love called her. Suddenly, there was a voice, "Come, Love, I will take you." It was an elder. So blessed and overjoyed, Love even forgot to ask the elder where they were going. When they arrived at dry land, the elder went her own way. Realizing how much was owed the elder, Love asked Knowledge, another elder, "Who Helped me?""It was Time," Knowledge answered."Time?" asked Love. "But why did Time help me?"Knowledge smiled with deep wisdom and answered, "Because only Time is capable of understanding how valuable Love is."从前有一个岛，所有的情感都住在那里：幸福、悲伤、知识和所有其它的，爱也不例外。一天，所有的情感听说小岛即将沉没，因此建造小船，纷纷离开，除了爱。爱是唯一留下来的，因为它希望能坚持到最后一刻。小岛即将沉没了，爱决定请求帮助。富有驾着一艘大船从爱身边经过，爱说，“富有，你能带上我么？”富有回答说：“不行，我的船上载满金银财宝，没有你的地方。”虚荣坐在漂亮的小船中从爱身边驶过，爱问：“虚荣，你能帮助我么？”虚荣说：“不行，你全身湿透，会弄脏我的船。”悲伤的船靠近了，爱问：“悲伤，请带我走吧。”“哦... 爱，我太难过了，想一个人呆着。”幸福经过爱的身边，它太开心了，根本没听见爱在呼唤。突然，一个声音喊道：“来，爱，我带你走。” 声音来自“年老”。爱太高兴了，甚至忘了问他们即将去何方。当他们来到岸上，年老自己离开了。爱突然意识到“年老”给了它多大的帮助。于是，爱问另一位老者--知识：“谁帮助了我？”知识说：“是时间。”“时间？”爱问：“但是时间为什么帮助我？”知识睿智地微笑道：“因为只有时间了解爱的价值。”The paradox of our time in history is that we have taller buildings, but shorter tempers; wider freeways, but narrower viewpoints; we spend more, but have less; we buy more but enjoy less. 我们这个时代在历史上的说法就是我们拥有更高的建筑，但是有更暴的脾气；我们拥有更宽阔的高速公路，却有更狭隘的观点；我们花费得更多，拥有得却更少；我们购买得更多却享受得更少。 We have bigger houses and smaller families; more conveniences, but less time; we have more degrees, but less sense; more knowledge, but less judgment; more experts, but more problems; more medicine, but less wellness. 我们的房子越来越大，家庭却越来越小；便利越来越多，时间却越来越少；学位越来越多，感觉却越来越少；知识越来越多，观点却越来越少；专家越来越多，问题也越来越多；药物越来越多，健康却越来越少。 We drink too much, spend too recklessly, laugh too little, drive too fast, get too angry too quickly, stay up too late, get up too tired, read too little, watch TV too much, and pray too seldom. 我们喝得太多，花钱大手大脚，笑得太少，开车太快，易怒，熬夜，赖床，书读得越来越少，电视看得越来越多，却很少向上帝祈祷。 We talk too much, love too seldom, and hate too often. We’ve learned how to make a living, but not a life; we’ve added years to life, not life to years. 我们常常夸夸其谈，却很少付出爱心，且常常心中充满了仇恨。我们学会了如何谋生，而不知如何生活。我们延长了生命的期限，而不是生活的期限。 We’ve been all the way to the moon and back, but have trouble crossing the street to meet the new neighbor. We’ve conquered outer space, but not inner space; we’ve done larger things, but not better things. 我们登上了月球，并成功返回，却不能穿过街道去拜访新邻居。我们已经征服了太空，却征服不了自己的内心；我们的事业越做越大，但质量却没有提高。 We’ve cleaned up the air, but polluted the soul; we’ve split the atom, but not our prejudice. We write more, but learn less; we plan more, but accomplish less. 我们清洁了空气，却污染了灵魂；我们分离了原子，却无法驱除我们的偏见；我们写得更多，学到的却更少；我们的计划更多，完成的却更少。 We’ve learned to rush, but not to wait; we have higher incomes, but, lower morals. 我们学会了奔跑，却忘记了如何等待；我们的收入越来越高，道德水平却越来越低。 We build more computers to hold more information to produce more copies than ever, but have less communication; we’ve become long on quantity, but short on quality. 我们制造了更多的计算机来存储更多的信息，制造了最多的副本，却减少了交流；我们开始渴望数量，但忽视了质量。 These are the days of two incomes, but more divorce; of fancier houses, but more broken homes. 这个时代有双收入，但也有了更高的离婚率；有更华丽的房屋，却有更多破碎的家庭。 These are the days of quick trips, disposable diapers, throw away morality, one night stands, overweight bodies, and pills that do everything from cheer, to quiet, to kill. Where are we heading...? 这个时代有了快速旅游，免洗尿布，却抛弃了道德、一夜情、超重的身体，以及可以从快乐中走向静止和自杀的药物。我们将走向何方……？ If we die tomorrow, the company that we are working for could easily replace us in a matter of days. But the family we left behind will feel the loss for the rest of their lives. 如果我们明天就死掉，我们为之工作的公司可能会在一天内很轻易地找人代替我们的位置。但是当我们离开家人后，他们的余生将会在失落中度过。 And come to think of it, we pour ourselves more into work than to our family an unwise investment indeed. 考虑一下吧，我们将自己的时间更多地投入到工作中，而放弃与家人在一起的时光，实在并非明智之举。 So what is the morale of the story?那么这则故事的主旨是什么呢?Don’t work too hard... and you know what’s the full word of family? 不要工作得太辛苦，你知道家的全称吗？ FAMILY = (F)ATHER (A)ND (M)OTHER, (I) (L)OVE (Y)OU.
教育 这个话题无论在何时厚实受到大家关注的，人类离不开教育，教育才会成长。下面是我为大家整理的关于教育的精选 议论文 ，欢迎大家一起来分享!关于教育的精选
我是乾宝宝 2人参与回答 2023-12-07 写作思路：简要概括，侧重体现成果、创新能力和领导能力。理工科论文的学术价值主要是采用了什么新方法、新工艺，产生了多少经济效益等。文科论文的学术价值主要看挖掘到了
CSYMiracle 3人参与回答 2023-12-10 我的父母来自于农村。他们的一生很平凡，没有享过多少福，因家庭条件的原因，早年就退学了，没有受过高等教育。在外人眼里，他们是那样平凡，可在我心中，父母是我生活的全
肥猫啃鱼头 3人参与回答 2023-12-10 特长：事故分析及处理绝招：优化大、小指标，节能增效
公山虚1 3人参与回答 2023-12-11 论法律在生活中的作用 俗话说“无规矩不成方圆”,这里所说的规矩不就是法律吗？在社会中必须有一定的约束才能让社会和谐发展，那么法在现实生活中究竟起什么作用呢？这
装璜专家 2人参与回答 2023-12-08 