洋洋捌月
版面费高、稿费高等。bmc是生物医学领域的一家独立的新型出版社,以出版网络版期刊为主,其中因为成本如版面费高、稿费高等,导致了该杂志价格昂贵的原因,其中该杂志汇集的知识丰富。
宇晨yuchen
BMC杂志在世界上属什么级别?P53, Somatostatin receptor 2a and Chromogranin A immunostaining as prognostic markers in high grade gastroenteropancreatic neuroendocrine neoplasms.Abstract:BACKGROUND:High grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) with a Ki67 proliferation index > 20%, include well-differentiated tumours grade 3 (NET G3) and poorly differentiated (PD) neuroendocrine carcinomas (NEC). Abnormal p53-expression is a feature of PD tumours, while expression of chromogranin A (CgA) and somatostatin-receptor 2a (SSTR-2a) may be a feature of well-differentiated tumours. The aim of this study was to elucidate the expression and prognostic value of these three markers in 163 GEP-NEN patients with a Ki67-index > 20%. METHOD:Clinical data, histopathology and overall survival were analysed according to Kaplan-Meier's method and Cox regression. The expression of SSTR-2a, CgA and synaptophysin was analysed in tumour specimens by immunohistochemistry, and semi-quantitatively scored as negative ( 30%). P53 was defined as normal when scored as heterogeneously positive (1-30%), and abnormal when negative (0%) or strongly positive (> 30%). RESULTS:In multivariate analysis, better survival was observed among patients with heterogeneously positive p53 compared to strongly positive (p 20%. Patients with heterogeneously positive p53 had the best prognosis. SSTR-2a was a positive prognostic marker in pancreatic NEN. Negative CgA was associated with a significantly worse OS compared to heterogeneously positive CgA-expression in a multivariate sub-analysis. Lower Ki67 index correlated significantly with heterogeneously positive p53, positive SSTR-2a and CgA expression.展开更多BMC CANCERBMC CANCER最新影响因子:期刊ISSN:1471-2407研究方向:医学-肿瘤学CiteScore:出版年份:2001出版地区:ENGLAND出版周期:Bimonthly是否OA:YES期刊官方网址:...期刊投稿网址:期刊coverage:Science Citation Index Expanded (科学引文索引扩展)NCBI查询:PubMed Central (PMC)链接全文检索 (pubmed central)
1、《读者》 2、《知音》 3、《青年文学家》 4、《半月谈》 5、《青年文摘》 6、《法制博览》 7、《家庭健康》 8、《老年教育
BMC系列杂志属于peer review中的bottom up类型的,即邀请reviewer,要求其填写report时具体给出对manuscript的意见,re
1.《收获》 《收获》是1957年7月创办于的一份大型文学双月刊,创办人为巴金和靳以。该杂志以刊登中长篇小说为主,2018年3月,获“2017年百强社科期刊”荣
音乐类核心期刊有《中国音乐学》;《音乐研究》;《中国音乐》;《中 央音乐学院学报》;《人民音乐》;《黄钟》;《音乐艺术》。 音乐是人们生活中不可缺少的一部分,音
版面费高、稿费高等。bmc是生物医学领域的一家独立的新型出版社,以出版网络版期刊为主,其中因为成本如版面费高、稿费高等,导致了该杂志价格昂贵的原因,其中该杂志汇